Subchronic toxicity of piperine in piper nigrum on the histology of the kidney, liver, and lungs of mice (Mus musculus L.)

Introduction: Piperine is a compound that has many health benefits, but piperin toxic effects endanger the human body. The purpose of this study was to determine dose subchronic piperine administration using histology liver, kidneys, and lungs mice (Mus musculus L).Method: This quasi-experimental research with posttest only control group design. Thirty male BALB/c were divided into five groups. administered orally mice. normal four treatment groups at dosage 17.5, 35, 70, 140 mg/kg body weight for 21 days. At day-22, removed prepared HE staining technique. Scores kidney, lung damage are recorded. data analyzed one-way ANOVA post hoc Tukey test.Result: liver histological score after doses significantly different from group. kidney scores showed significant differences conclusion mice.Conclusion: should not be used 35 or larger.